Quartz PCI in Published Research
What if the key to unlocking cancer immunotherapy was already living inside you?
Lung cancer remains the leading cause of cancer-related deaths worldwide. Immunotherapy has changed the game, but too many patients still do not respond. Scientists have long suspected gut bacteria play a role. Now, there is evidence of exactly how.
A research team publishing in Nature Communications identified that tiny nano-sized vesicles shed by Bifidobacterium, a common gut commensal, can travel from the intestine, cross tissue barriers, and accumulate directly inside lung tumors.
Once there, they prime tumor cells to express more PD-L1. That makes the cancer more visible, and more vulnerable, to anti-PD-1 immunotherapy.
In mouse models, combining these vesicles with anti-PD-1 significantly reduced tumor growth, increased tumor-infiltrating CD8+ T cells, and shifted the tumor immune environment toward an anti-cancer state.
To map exactly where and how this was happening inside tumor tissue, the team turned to spatial profiling using the NanoString GeoMx Digital Spatial Profiling instrument, with image analysis supported by Quartz PCI.
The result: a measurable, spatially resolved picture of PD-L1 upregulation and immune cell infiltration across treatment groups.
The gut-lung axis is no longer a hypothesis. It is a potential therapeutic target, and imaging made it visible.
All rights for the excerpts and images remain with the authors and the full article is found here.
Preet, R., Islam, M.A., Shim, J. et al. Gut commensal Bifidobacterium-derived extracellular vesicles modulate the therapeutic effects of anti-PD-1 in lung cancer. Nature Communications 16, 3500 (2025).
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Clean water is not a luxury. It is a right. And science is finding new ways to protect it.
Synthetic dyes from industrial processes are among the most persistent and harmful contaminants in our water systems.
Conventional treatment methods struggle to break them down.
A research team at the University of Cagliari set out to change that. They developed nanocomposites using a simple, sustainable ingredient: an extract from the microalgae Chlorella vulgaris.
No hazardous chemicals. No energy-intensive processes.
The result was a photocatalytic material capable of breaking down Congo Red, a toxic industrial dye, using UV light.
To characterize the material at the nanoscale, the team used Quartz PCI to process their SEM micrographs, capturing the hierarchical structure of the nanocomposites with precision.
The findings: up to 49% dye removal in 180 minutes, at a low catalyst loading, with performance that held steady across varying light intensities.
That last point matters. It means the system does not need to be pushed harder to work. It is already operating efficiently.
Cleaner water, greener chemistry, and a more rational use of energy. That is the direction this research points.
All rights for the excerpts and images remain with the authors and the full article is found here.
Zedda, F., Atzori, F., Casu, S., Sidorowicz, A., Fais, G., Desogus, F., Licheri, R., Porcu, S., Cao, G., Lutzu, G.A., & Concas, A. (2026). Green-Synthesized Ag/Zn Nanocomposites from Chlorella vulgaris Polar Extract: Sustainable Photocatalytic Water Remediation and Kinetic Modeling. Sustainability, 18, 4607.
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Cleaner Water for More People Could Start with Using Less to Make More
Arsenic in drinking water is a global health crisis affecting hundreds of millions of people.
Existing filtration membranes can remove it, but they are expensive and material-intensive to produce.
A research team at the University of Girona in Spain set out to change that.
Their approach was to deposit polymer inclusion membranes onto simple porous supports, such as cellulose filter paper and commercial PVDF membrane, using up to 75% less material than conventional methods.
To confirm the membranes were properly formed and structurally sound, the team used scanning electron microscopy with Quartz PCI software to evaluate surface morphology, layer uniformity, and the adhesion between the polymer phase and the porous support.
The results were compelling. The supported membranes achieved 90 to 95% arsenic transport efficiency, comparable to standard membranes, and retained around 70% efficiency after three reuse cycles.
Less material. Equal performance. Reusable.
This is the kind of innovation that makes water purification technology more accessible, more sustainable, and ultimately more equitable for communities that need it most.
All rights for the excerpts and images remain with the authors and the full article is found here.
Khatir N, Anticó E, Fontàs C. A Novel Supported Polymer Inclusion Membrane Concept for Reagent-Efficient Membrane Design. Membranes. 2026;16(4):135.
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A 3D scaffold that could change how we grow cells — and one day, how we heal.
Traditional cell culture substrates have a fundamental limitation.
They are flat. Rigid. Poor at mimicking the real environment inside the human body.
Researchers at the University of North Dakota set out to change that.
The Obstacle:
Growing vascular cells in a way that reflects how they actually behave in living tissue requires a scaffold with tunable porosity, flexibility, and biocompatibility. Existing materials could not reliably deliver all three.
The Solution:
The team engineered a graphene oxide-based porous 3D mesh, combining graphene oxide with polyethylene glycol and a salt-leaching process to create a scaffold with precisely controllable pore size and mechanical properties. To characterize the mesh structure and analyze the cells cultured within it, the team used a scanning electron microscope paired with Quartz PCI software for imaging and pore size analysis across 500 pores per sample.
The Humanity:
When vascular endothelial cells and fibroblasts were cultured on this scaffold, they did not just survive. They organized themselves into structures resembling capillaries, the smallest blood vessels in the body. That is a meaningful step toward building lab environments that could accelerate drug testing, reduce animal trials, and eventually support tissue engineering for human medicine.
A patent granted. A foundation laid.
All rights for the excerpts and images remain with the inventors and assignee. The full patent is found here.
US Patent No. 12,077,776 B2 — Zhang, Y., Zhao, J.X., Darland, D. — University of North Dakota. Granted: September 3, 2024.
Congratulations to the inventors on the grant of this patent, and thank you for including Quartz PCI in your work.
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Understanding How Plants Grow Could Help Us Feed the World.
Every crop plant depends on healthy cell division and reproduction to thrive.
When those processes go wrong, yields drop, flowers fail, and growth stalls.
Understanding why is one of the most important questions in plant biology.
A research team at the University of Toronto, Scarborough set out to investigate what happens when a gene called HOP2, normally active only during meiosis, becomes overexpressed in the common research plant Arabidopsis.
The results were striking. Plants with elevated HOP2 levels showed stunted growth, misshapen flowers, altered leaf patterns, and severely reduced fertility.
To document the structural defects at the cellular level, the team used scanning electron microscopy with images captured using Quartz PCI.
The SEM micrographs revealed detailed floral organ abnormalities that would have been impossible to characterize with light microscopy alone.
The findings open a new window into how a single gene, when expressed at the wrong time or in the wrong place, can cascade into widespread developmental failure.
That knowledge brings us closer to understanding the genetic switches that govern plant health, resilience, and ultimately, food production.
All rights for the excerpts and images remain with the authors and the full article is found here.
Garrido AN, Francom T, Divan S, Kesserwan M, Daradur J, Riggs CD. Overexpression of HOP2 induces developmental defects and compromises growth in Arabidopsis. bioRxiv. 2021.
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A next-generation dental adhesive has matched commercial standards — without Bisphenol A.
Dental restorations fail from the inside out.
Water seeps into the bond, collagen degrades, and the restoration fails before it should.
Researchers at Instituto Universitário Egas Moniz tackled this by replacing Bis-GMA with a novel dendrimer called G-IEMA, creating a BPA-free adhesive built to last longer.
The obstacle: existing universal adhesives attract and retain water at the bonding interface, the primary driver of long-term failure.
The solution: a reformulated adhesive with lower hydrophilicity, tested against two leading commercial products across four adhesive groups and two bonding strategies.
Quartz PCI software was used to analyze silver nitrate penetration along the dentin interface, delivering the precise imaging needed to quantify nanoleakage at the microscopic level.
After three months of aging, both experimental adhesives showed significantly less nanoleakage than the commercial alternatives.
Bond strength matched commercial adhesives from day one.
The humanity: restorations that hold longer mean fewer repeat procedures, less chair time, and better long-term outcomes for patients.
All rights for the excerpts and images remain with the authors and the full article is found here.
Vasconcelos e Cruz, J., Delgado, A.H.S., Félix, S., Brito, J., Gonçalves, L., & Polido, M. (2022). Improving Properties of an Experimental Universal Adhesive by Adding a Multifunctional Dendrimer (G-IEMA): Bond Strength and Nanoleakage Evaluation. Polymers, 14(7), 1462.
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Unlocking a 20-Million-Year-Old Geological Mystery to Better Understand Our Planet
For over 30 years, the origin of unusual dolomite formations in Kuwait's Al-Subiya sabkha had scientists puzzled.
How does a rare mineral form in sediment with no obvious precursor, in the middle of an ancient coastal mud volcano?
That was the obstacle.
A research team from the University of Toronto set out to investigate a recently discovered early-middle Miocene mud volcano outcrop, combining field sampling with geochemical analysis, electron probe microanalysis, and scanning electron microscopy.
Quartz PCI image management software was used for SEM image acquisition, helping the team capture and document the fine-scale mineral structures at the heart of the mystery.
The findings revealed that dolomite formation was driven by an interconnected set of conditions: hydrocarbon seepage, hypersaline seawater, and the burrowing activity of ancient crustaceans that created channels for methane-rich fluids to mix with the surrounding sediment.
Understanding how and where dolomite forms matter beyond geology.
Dolomite-bearing formations are significant hydrocarbon reservoirs worldwide, and this research adds a critical piece to our understanding of how Earth's subsurface systems work.
All rights for the excerpts and images remain with the authors and the full article is found here.
Alibrahim, A., Duane, M. J., & Dittrich, M. (2021). Dolomite genesis in bioturbated marine zones of an early-middle Miocene coastal mud volcano outcrop (Kuwait). Scientific Reports, 11, 6636.
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Building Stronger Materials for a Healthier, More Sustainable World.
Advances in materials science are helping improve the reliability of technologies used in healthcare, environmental monitoring, and beyond.
This research examines how physical aging impacts the fracture behavior of chalcogenide glass fibers, materials widely used in infrared sensing and biosensing applications. Understanding how these fibers change over time is critical to ensuring long-term performance and durability in real-world conditions.
By analyzing fracture surfaces and key mechanical properties such as tensile strength and flaw depth, the study provides valuable insight into how environmental factors influence material integrity.
Quartz Imaging is proud to be associated through the use our software.
This work highlights how advanced imaging and analysis tools contribute to building more reliable materials that ultimately support human health and environmental sustainability.
This paper was published on ScienceDirect.com
All rights for the excerpts and images remain with the authors.
Yang, G., Chen, H., Boussard-Plédel, C., Sangleboeuf, J.-C., Bureau, B. Effect of physical aging on fracture behavior of Te₂As₃Se₅ glass fibers. Ceramics International, 2015.
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